A power back thrives in schemes that use inside zone, counter runs, and CFB 25 Coins downhill plays (e.g., Pro Style, Power Run).
A speed back benefits from outside runs, stretch plays, and misdirection (e.g., Spread Option, Air Raid screens).
If you have multiple solid backs, a balanced or two-back system (e.g., Triple Option, Pro Style) allows for rotations.
Wide Receivers (WR):

Elite route runners and possession receivers fit well in West Coast and Pro Style offenses.
Speedsters and deep threats excel in Air Raid or Spread offenses that emphasize vertical passing.
Balanced WR groups can adapt to most playbooks but benefit from a play-action-heavy approach.
Tight Ends (TE):

Receiving-focused TEs thrive in Pro Style, West Coast, and Spread playbooks where they can be mismatches.
Blocking TEs are valuable in run-heavy playbooks, like Power Run and Triple Option schemes.
Hybrid TEs that can block and catch give you flexibility in multiple formations.
Offensive Line (OL):

A strong OL can handle power runs and deep dropbacks, making Pro Style or Power Run ideal.
A weaker OL benefits from quick passing plays or schemes with misdirection (e.g., Spread Option, West Coast).
Defense
Defensive Line (DL):

A dominant pass rush pairs well with aggressive, blitz-heavy schemes (e.g., 4-3 or Multiple Fronts).
A strong run-stuffing DL fits in a 3-4 or Power-based defense, controlling the trenches.
If your DL lacks elite talent, a scheme that prioritizes coverage and disguised pressures may work better.
Linebackers (LBs):

Fast and versatile LBs excel in a 3-4 scheme where they can blitz and drop into coverage.
Run-stopping LBs fit in a 4-3 system that prioritizes gap control.
Coverage-focused LBs are ideal for Nickel and Dime-heavy playbooks.
Secondary (DBs):

Lockdown man-to-man corners allow you to run aggressive schemes like press coverage and blitz-heavy defenses.
Zone-specialist DBs are best suited for Cover 2 or Cover 3-heavy playbooks.
If your secondary is weak, running more zone or hybrid schemes can help minimize exposure.
Special Teams & Overall Strategy
If your team has elite returners, consider aggressive special teams play to gain extra field position.
A strong-legged kicker can influence decision-making on fourth downs and field position battles.
If your roster lacks elite talent, a scheme that emphasizes ball control and NCAA Football 25 Coins time of possession may be best.