To unlock The Vile Alchemist's services in Path of Exile 2, you will need to POE2 Currency progress through the Grim Tangle zone and meet certain conditions. Here's how to unlock his services:

1. Progress Through the Grim Tangle Zone:
As you explore the Grim Tangle zone, you will encounter various fungal and chaos-themed enemies.
The Vile Alchemist is located deeper within the zone, often near the fungal caverns or other chaotic, poisonous areas.
While progressing, you'll need to complete related quests or challenges to reach the area where The Vile Alchemist resides.
2. Defeat Key Bosses or Clear Key Areas:
In the Grim Tangle, some areas or quests may require you to defeat specific mini-bosses or progress through certain regions (including Ervig, The Rotten Druid).
After defeating key bosses or completing certain objectives in the zone, The Vile Alchemist's services will become available to you.
3. Unlocking Access to Crafting:
Once you have reached the appropriate area and met the necessary progression requirements, you will be able to interact with The Vile Alchemist.
You may need to unlock the crafting system or specific alchemy-related activities, such as potion crafting or chaos resistance items.
Keep an eye out for any progression markers on your map, quests, or objectives that indicate access to his services.
4. Required Currency or Materials:
To use his crafting services, make sure you have the necessary materials (often involving chaos-infused crafting materials or specific reagents).
He may require certain currencies or items to craft specialized potions, chaos resistance gear, or even unique items with poison-related properties.
5. Check for Special Quests or Challenges:
Some services may be unlocked through special side quests or challenges within the zone. Make sure to keep an eye out for these optional objectives as they may unlock additional services from The Vile Alchemist.
Once you've completed these steps, you should have full access to buy POE2 Currency The Vile Alchemist and his valuable services in Path of Exile 2.